Scientific Foundation

The Biology Powering NeuroBiome AI

Our model is built on a foundation of peer-reviewed research establishing the gut-brain axis as a critical factor in Alzheimer's disease development and progression.

Gut Microbiome Dysbiosis in Alzheimer's Disease

Research has established that the gut microbiome composition is significantly altered in Alzheimer's disease. This dysbiosis, an imbalance in microbial communities, is characterized by reduced diversity, loss of beneficial bacteria, and overgrowth of pro-inflammatory species.

Key Scientific Findings:

  • 1
    Decreased abundance of short-chain fatty acid (SCFA) producers like Faecalibacterium and Roseburia
  • 2
    Increased levels of pro-inflammatory bacteria including certain Bacteroides and Escherichia species
  • 3
    Altered Firmicutes-to-Bacteroidetes ratio compared to healthy controls
  • 4
    Disruption of the intestinal barrier leading to increased permeability ('leaky gut')
  • 5
    Systemic inflammation driven by bacterial lipopolysaccharides (LPS) entering circulation
<50%
Alpha diversity reduction in Alzheimer's gut microbiome
3-5x
Reduction in IPA-producing bacteria in disease models
Years
Early gut changes detectable before cognitive symptoms
Built with v0